ICAD peptide

GeneTex

ICAD peptide

7

The peptide is used for blocking the activity of DFF45 (GTX28409). Incubatingthe peptide with equal volume of antibody for 30 min at 37C usually completely blocks theantibody activity in Western blotting.

Research Use Only

0.20 mg/ml

Unconjugated

Liquid

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the Caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which was cleaved by Caspase 3 during apoptosis. A mouse homologue of human DFF was identified as inhibitor of caspase activated deoxyribonuclease (ICAD). Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death.

-20°C

12352202