Icilin [36945-98-9]

MedChem Express

Icilin [36945-98-9]

10

36945-98-9

Research Use Only

99.26

C16H13N3O4

311.29

Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 microM). Icilin is a super-cooling agent [1][2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response[3].

O=C1N(C2=CC=CC=C2O)CC=C(C3=CC=CC([N+]([O-])=O)=C3)N1

-20°C,2°C to 8°C

12352200