ICMT-IN-35

MedChem Express

ICMT-IN-35

14

Research Use Only

C25H29N3O2S

435.58

ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 microM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity (IC50=0.8 microM) against metastatic pancreatic cancer cell lines[1].

C/C(CCN(N=N1)C=C1CCC(C=C2)=CC=C2C3=CC=CC=C3)=C/SCCC(OC)=O

12352200