ICSN3250 (hydrochloride)
HY-112774A
Molecular Weight633.13
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameICSN3250 (hydrochloride)
- Delivery Days Customer999
- CertificationResearch Use Only
- Molecular FormulaC31H41ClN4O8
- Molecular Weight633.13
- Scientific DescriptionICSN3250 hydrochloride is a halitulin analogue and a selective mTORC1 inhibitor. ICSN3250 hydrochloride directly binds to mTORs FRB domain and displaces phosphatidic acid (PA), reversing mTORC1 activation. ICSN3250 hydrochloride shows high cytotoxicity in cancer cells (nanomolar concentration) through a caspase-independent cell death mechanism. ICSN3250 hydrochloride specifically inhibits the mTORC1 pathway, inducing autophagy and G0-G1 cell-cycle arrest in cancer cells. ICSN3250 hydrochloride can be used for the study of cancer [1].
- SMILESOC1=CC(C2=CN(C=C2C3=CC([N+]([O-])=O)=C(O)C(O)=C3)CCCN4CCCCCCCCCCCC4)=CC([N+]([O-])=O)=C1O.Cl
- UNSPSC12352200