Idebenone

MedChem Express

Idebenone [58186-27-9]

10

58186-27-9

Research Use Only

99.37

C19H30O5

338.44

Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimers disease, Huntingtons disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC 50 =16.65 microM) [1] . Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells [2] . Idebenone quickly crosses the blood-brain barrier.

O=C1C(CCCCCCCCCCO)=C(C)C(C(OC)=C1OC)=O

-20°C,2°C to 8°C

12352200