IDH-305 [1628805-46-8]

TargetMol Chemicals

IDH-305 [1628805-46-8]

4

1628805-46-8

Chemical

Research Use Only

IDH-305

99.13%

C23H22F4N6O2

490.45

IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively.

3 years

C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1

-20°C

12352200