IDH-C227 --- IDH1 Inhibitor

Bioss

IDH-C227 --- IDH1 Inhibitor [1355324-14-9]

16

Research Use Only

98.0

IDH-C227 is a potent and selective IDH1 R132H inhibitor first reported in patent WO2012009678. It can inhibit the enzymatic activity of IDH1 R132H in vitro with an IC50 < 0.1 microM, and 2-HG production in HT1080 and U87MG cells with IC50 < 0.25 microM. Because the mutated form of IDH1 produces the metabolite, 2-hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas as well as other forms of cancer, IDH-C227 serves as a very useful chemical probe to study this novel target.

-20°C

51202000