IDO1 Activity Assay Kit for Inhibitor Screening

Aurora Biolabs

IDO1 Activity Assay Kit for Inhibitor Screening

12

Assay

Research Use Only

Tryptophan is an essential amino acid that is involved in protein synthesis and regulation of the local immune response by T lymphocytes. Indoleamine 2,3-dioxygenase-1 (IDO1) catalyzes oxidation of tryptophan to N-formylkynurenine (NFK), the initial and rate limiting step in the pathway of catabolism of tryptophan. Over expression of IDO1 in variety of cancers results in the depletion of Tryptophan and the accumulation of kynurenine, that have been proposed as mechanisms that contribute to the suppression of the immune response.

-80⁰C

41116133