iFluor(tm) 488 Conjugated Anti-Beta Catenin Antibody [SA30-04]

HUABIO

iFluor(tm) 488 Conjugated Anti-Beta Catenin Antibody [SA30-04]

2

ImmunoFluorescence, ImmunoCytoChemistry

Research Use Only

Monoclonal

SA30-04

1 mg/ml

Other Conjugate

CTNNB1

catenin beta 1

CTNNB, EVR7, MRD19, NEDSDV, armadillo, catenin beta-1, catenin (cadherin-associated protein), beta 1, 88kDa

Rabbit

IgG

Catenin beta-1

Catenin beta-1, also known as beta-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. Beta-catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. beta-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. Mutations and overexpression of beta-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. Alterations in the localization and expression levels of beta-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. beta-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

-20°C,2°C to 8°C

41116161