iFluor(tm) 488 Conjugated Anti-Cytokeratin 7 Antibody [ST50-05]

HUABIO

iFluor(tm) 488 Conjugated Anti-Cytokeratin 7 Antibody [ST50-05]

2

Flow Cytometry, ImmunoFluorescence

Research Use Only

Monoclonal

ST50-05

1 mg/ml

Other Conjugate

KRT7

keratin 7

CK7, K2C7, K7, SCL, keratin, type II cytoskeletal 7, CK-7, cytokeratin 7, keratin 7, type II, keratin, 55K type II cytoskeletal, keratin, simple epithelial type I, K7, sarcolectin, type II mesothelial keratin K7, type-II keratin Kb7

Rabbit

IgG

Keratin, type II cytoskeletal 7

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. Cytokeratin 7 (also known as sarcolectin) agglutinates normal and transformed cells with a high affinity for simple sugars. Cytokeratin 7 also inhibits the synthesis of interferon-dependent secondary proteins thus reversing the antiviral effect of interferon induction and restoring cells to their status ad primum. In normal and transformed cells, Cytokeratin 7 localizes to the membrane.

-20°C,2°C to 8°C

41116161