iFluor(tm) 488 Conjugated Anti-Cytokeratin 9 Antibody [SD201-09]

HUABIO

iFluor(tm) 488 Conjugated Anti-Cytokeratin 9 Antibody [SD201-09]

2

ImmunoFluorescence

Research Use Only

Monoclonal

SD201-09

1 mg/ml

Other Conjugate

KRT9

keratin 9

CK-9, EPPK, EPPK1, K9, keratin, type I cytoskeletal 9, cytokeratin 9, keratin 9, type I, type I cytoskeletal 9

Rabbit

IgG

Keratin, type I cytoskeletal 9

Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratin 9 is an unusually large, type I acidic cytokeratin that differentiates human plantar and palmar epidermal cells. Cytokeratin 9 localizes to the suprabasal layers as well as the upper epidermal layers such as the glandular ridges and interridges. The domains of cytokeratin 9 include a head, an alpha-helical coiled-coil-forming rod, and a tail; cytokeratin 9 shares significant homology with cytokeratin 10. Mutations in the cytokeratin 9 gene correlate with the development of epidermolytic palmoplantar keratoderma (EPPK), an autosomal dominant inherited skin disorder that is characterized by hyperkeratosis of the skin over the palms and soles.

-20°C,2°C to 8°C

41116161