iFluor(tm) 647 Conjugated Anti-Cytokeratin 18 Antibody [SZ80-07]

HUABIO

iFluor(tm) 647 Conjugated Anti-Cytokeratin 18 Antibody [SZ80-07]

2

ImmunoFluorescence

Research Use Only

Monoclonal

SZ80-07

1 mg/ml

Other Conjugate

KRT18

keratin 18

CK-18, CYK18, K18, keratin, type I cytoskeletal 18, cell proliferation-inducing gene 46 protein, cytokeratin 18, keratin 18, type I

Rabbit

IgG

Keratin, type I cytoskeletal 18

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner Cytokeratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Keratin 18 is often used together with Cytokeratin 8 and Cytokeratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

-20°C,2°C to 8°C

41116161