iFluor(tm) 647 Conjugated Anti-SATB2 Antibody [JM52-44]
HA720173F
ApplicationsFlow Cytometry, ImmunoFluorescence
Product group Antibodies
TargetSATB2
Overview
- SupplierHUABIO
- Product NameiFluor(tm) 647 Conjugated Anti-SATB2 Antibody [JM52-44]
- Delivery Days Customer2
- ApplicationsFlow Cytometry, ImmunoFluorescence
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDJM52-44
- Concentration1 mg/ml
- ConjugateOther Conjugate
- Gene ID23314
- Target nameSATB2
- Target descriptionSATB homeobox 2
- Target synonymsC2DELq32q33, DEL2Q32Q33, GLSS, DNA-binding protein SATB2, SATB family member 2, SATB2 fusion, special AT-rich sequence-binding protein 2
- HostRabbit
- IsotypeIgG
- Protein IDQ9UPW6
- Protein NameDNA-binding protein SATB2
- Scientific DescriptionSATB2 (Special AT-rich sequence-binding protein 2) is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41116161