iFluor(tm) 647 Conjugated Anti-Sodium Potassium ATPase Antibody [ST0533]

HUABIO

iFluor(tm) 647 Conjugated Anti-Sodium Potassium ATPase Antibody [ST0533]

2

Flow Cytometry, ImmunoFluorescence

Research Use Only

Monoclonal

ST0533

1 mg/ml

Other Conjugate

ATP1A1

ATPase Na+/K+ transporting subunit alpha 1

CMT2DD, HOMGSMR2, sodium/potassium-transporting ATPase subunit alpha-1, ATPase, Na+/K+ transporting, alpha 1 polypeptide, Na(+)/K(+) ATPase alpha-1 subunit, Na+/K+ ATPase 1, Na, K-ATPase, alpha-A catalytic polypeptide, Na,K-ATPase alpha-1 subunit, Na,K-ATPase catalytic subunit alpha-A protein, sodium pump subunit alpha-1, sodium-potassium ATPase catalytic subunit alpha-1, sodium-potassium-ATPase, alpha 1 polypeptide

Rabbit

IgG

Sodium/potassium-transporting ATPase subunit alpha-1

The sodium-potassium pump (sodium-potassium adenosine triphosphatase, also known as Na+/K+-ATPase, Na+/K+ pump, or sodium-potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na+/K+-ATPase helps maintain resting potential, affects transport, and regulates cellular volume. It also functions as a signal transducer/integrator to regulate the MAPK pathway, reactive oxygen species (ROS), as well as intracellular calcium. In fact, all cells expend a large fraction of the ATP they produce (typically 30% and up to 70% in nerve cells) to maintain their required cytosolic Na and K concentrations. For neurons, the Na+/K+-ATPase can be responsible for up to 3/4 of the cells energy expenditure. In many types of tissue, ATP consumption by the Na+/K+-ATPases have been related to glycolysis. This was first discovered in red blood cells (Schrier, 1966), but has later been evidenced in renal cells, smooth muscles surrounding the blood vessels,[6] and cardiac purkinje cells. Recently, glycolysis has also been shown to be of particular importance for Na+/K+-ATPases in skeletal muscles, where inhibition of glycogen breakdown (a substrate for glycolysis) leads to reduced Na+/K+-ATPase activity and lower force production.

-20°C,2°C to 8°C

41116161