IFN-gamma R1/CD119, Mouse (HEK293, His)

MedChem Express

IFN-gamma R1/CD119, Mouse (HEK293, His)

10

Research Use Only

98.0

Ifngr1

interferon gamma receptor 1

CD119; If; Ifgr; IFN-g; IFN-gamma receptor 1; IFN-gammaR; IFN-gamma-R1; IFN-gamma-R-alpha; Ifngr; INF-g receptor; interferon gamma receptor 1; interferon gamma receptor alpha-chain; Nk; Nktar

Interferon gamma receptor 1

IFN-gamma R1 (CD119), one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R1 forms the functional receptor with IFN-gamma R2. Upon binding with IFN-gamma, IFN-gamma R1 and IFN-gamma R2 oligomerize and transphosphorylate[1]. Then, JAK1 and JAK2 are phosphorylated and activated, and STAT1 is recruited to the receptor complex. Phosphorylated STAT1 translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54)[2]. IFN-gamma R1/CD119 Protein, Mouse (HEK293, His) is a recombinant mouse IFN-gamma R1 with C-terminal 6*His tag, which is produced in HEK293 cells.

-20°C

41116100