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ICC/IF analysis of methanol-fixed MCF cells using GTX50433 IGF1R beta antibody.
ICC/IF analysis of methanol-fixed MCF cells using GTX50433 IGF1R beta antibody.
ICC/IF analysis of methanol-fixed MCF cells using GTX50433 IGF1R beta antibody.

IGF1R beta antibody

GTX50433
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetIGF1R
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Overview

  • Supplier
    GeneTex
  • Product Name
    IGF1R antibody - Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:1000. ICC/IF: 1:100-1:200. IHC-P: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3480
  • Target name
    IGF1R
  • Target description
    insulin like growth factor 1 receptor
  • Target synonyms
    CD221; IGF-I receptor; IGFIR; IGFR; insulin-like growth factor 1 receptor; JTK13; soluble IGF1R variant 1; soluble IGF1R variant 2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP08069
  • Protein Name
    Insulin-like growth factor 1 receptor
  • Scientific Description
    This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Critical role of SOX2-IGF2 signaling in aggressiveness of bladder cancer. Chiu YF et al., 2020 May 19, Sci Rep
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  • IGFBP7 Drives Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Lung Cancer. Wu SG et al., 2019 Jan 2, Cancers (Basel)
    Read more