IKK gamma peptide

GeneTex

IKK gamma peptide

9

The peptide is used for blocking the antibody activity of IKKg (GTX27890). Itusually blocks the antibody activity completely in Western blot by incubating the peptide withequal volume of antibody for 30 min at 37C

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

Pro inflammatory cytokines activate the transcription factor NF kappa B by stimulating the activity of a protein kinase that phosphorylates Ikappa B, an inhibitor of NF kappa B, at sites that trigger its ubiquitination and degradation. A large, cytokine responsive Ikappa B kinase (IKK) complex has been purified and the genes encoding 2 of its subunits have been cloned. These subunits, IKK alpha and Ikk beta, are protein kinases whose function is needed for NF kappa B activation by pro inflammatory stimuli. IKK is composed of similar amounts of IKK alpha, Ikk beta, which are differentially processed forms of a third subunit, IKK gamma. Ikk gamma interacts preferentially with IKK beta and is required for the activation of the IKK complex.

-20°C

12352202