IKKbeta-IN-1 [2410423-31-1]

MedChem Express

IKKbeta-IN-1 [2410423-31-1]

10

2410423-31-1

Research Use Only

C31H30N4O4S

554.66

IKKbeta-IN-1 is a potent and orally active IkappaB (IKK-beta) inhibitor with IC50 of 0.20 microM. IKKbeta-IN-1 can reduce PGE2 and TNF-alpha production in mouse macrophage cells. IKKbeta-IN-1 has the ability to protect mice against septic shock induced mortality[1].

N#CC1=CC=C(OC2=CC=C(/C=C(SC(N3C4=CC=C(OCCCN5CCN(C)CC5)C=C4)=O)/C3=O)C=C2)C=C1

12131703