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IL-12 Responsive STAT4 Luciferase Reporter HEK293 Cell Line

82836
BPS Bioscience
CategoryCell Culture
Product group Cell Culture
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    IL-12 Responsive STAT4 Luciferase Reporter HEK293 Cell Line
  • Delivery Days Customer
    23
  • Applications
    Neutralisation/Blocking
  • Certification
    Research Use Only
  • Scientific Description
    IL-12 Responsive STAT4 Luciferase Reporter HEK293 Cell Line was engineered to express firefly luciferase under the control of interferon-gamma-activated sequence of the interferon regulatory factor 1 (GAS-IRF1) promoter. It also expresses human STAT4 (signal transducer and activator of transcription 4) (NM_001243835.1), and the human IL-12 receptor complex (IL12Rbeta1 NM_005535.3 and IL12Rbeta2 NM_001559.3). With this cell line, IL-12 activity can be monitored by measuring luciferase activity. The functionality of the IL-12 Responsive STAT4 Luciferase Reporter HEK293 Cell Line was validated in dose-response assays using a recombinant human interleukin 12 (human IL-23; p35 + p40) and inhibition assays using an IL-12 neutralizing antibody (#102108). Figure 1. Illustration of the mechanism of action of the IL-12 Responsive STAT4 Luciferase Reporter HEK293 Cell Line. Interested in having us perform the screening and profiling of inhibitors or blocking antibodies? Visit our Immunotherapy Biochemical Screening Services.
  • Storage Instruction
    Liquid Nitrogen
  • UNSPSC
    12352207