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IL-15 Responsive Luciferase Reporter Cell Line

IL-15 Responsive Luciferase Reporter Cell Line

Research Use Only
78402
BPS Bioscience
Category(Cell) Culture
Product group (Cell) Culture
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    IL-15 Responsive Luciferase Reporter Cell Line
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Scientific Description
    This recombinant Jurkat cell line is a biologically relevant system to measure activation of the IL-15 cytokine receptor by IL-15. The cells were engineered for constitutive expression of human CD122 (IL-15Rbeta; IL-2Rbeta; NM_000878.4), and conditional expression of firefly luciferase driven by STAT5 response elements located upstream of the minimal TATA promoter. Expression of CD122 allows formation of a functional IL-15 receptor at the surface of Jurkat cells, which naturally express high levels of CD132 (also known as IL-15 receptor subunit gammac). Activation of the STAT5 signaling pathway in response to IL-15 or IL-15 analogs can be monitored by measuring luciferase activity.
  • Storage Instruction
    Liquid Nitrogen
  • UNSPSC
    12352207

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