IL-36gamma (aa 13-164) (mouse) (rec.) (FLAG)
AG-40B-0105
Overview
- SupplierAdipoGen Life Sciences
- Product NameIL-36gamma (aa 13-164) (mouse) (rec.) (FLAG)
- Delivery Days Customer10
- CertificationResearch Use Only
- Concentration0.1 mg/ml
- Estimated Purity>95%
- Protein IDQ8R460
- Protein NameInterleukin-36 gamma
- Scientific DescriptionIL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. - Protein. Mouse IL-36gamma (aa Gly13-Ser164) is fused at the C-terminus to a FLAG®-tag. Source: E. coli. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Purity: >95% (SDS-PAGE). IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352202