IL-36Ra (human) Matched Pair Detection Set
AG-46B-0006
Overview
- SupplierAdipoGen Life Sciences
- Product NameIL-36Ra (human) Matched Pair Detection Set
- Delivery Days Customer10
- ApplicationsELISA
- Assay Detection Range0.78 to 50ng/ml
- Assay Sensitivity0.5ng/ml
- Assay SpecificityDetects human IL-36Ra.
- CertificationResearch Use Only
- Scientific DescriptionIL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes. - Matched Pair Detection Set. Detects human IL-36Ra. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 0.78 to 50ng/ml. Sensitivity: 0.5ng/ml. IL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC41116133