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IL10 antibody [GT5111]

Name: IL10 antibody [GT5111]
SKU: GTX632359_G10
Availability: BackOrder

GTX632359

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetIL10

Overview

Supplier
GeneTex
Product Name
IL10 antibody [GT5111]
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
GT5111
Concentration
1.19 mg/ml
Conjugate
Unconjugated
Gene ID3586
Target name
IL10
Target description
interleukin 10
Target synonyms
CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin-10, T-cell growth inhibitory factor, cytokine synthesis inhibitory factor
Host
Mouse
Isotype
IgG1
Protein IDP22301
Protein Name
Interleukin-10
Scientific Description
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

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Méndez-Lara KA, Letelier N, Farré N, et al. Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice. Antioxidants (Basel). 2020,9(11). doi: 10.3390/antiox9111162
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Luo Q, Cheng D, Huang C, et al. Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats. Molecules. 2019,24(6). doi: 10.3390/molecules24061139
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Singh AK, Bhadauria AS, Kumar U, et al. Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals. Sci Rep. 2018,8(1):5932. doi: 10.1038/s41598-018-24288-0
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