IL21 Receptor peptide

GeneTex

IL21 Receptor peptide

9

The peptide is used for blocking the antibody activity of anti-IL-21R (cat. no GTX25980). It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C.

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21. The receptor for IL-21(IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.

-20°C

12352202