IL7 Antibody

Cusabio

IL7 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

IL7

interleukin 7

IL-7, IMD130, interleukin-7

Rabbit

IgG

Interleukin-7

IL-7 plays a key role in lymphopoiesis and lymphoid homeostasis. Stromal and epithelial cells within the bone marrow and thymus produce IL-7. The primary targets of IL-7 are T cells, B cells, and dendritic cells. IL-7 is crucial for T cell development, the importance of which is underscored by the lack of T cells in both mice and humans that are deficient in IL-7/IL-7R signaling. While IL-7 appears to be required for B cell development in mice, the role of IL-7 in human B cell development is unclear. In addition to its effects on T cell lymphopoiesis, IL-7 promotes the maintenance and survival of naive and memory alphabeta T cells, as well as gammadelta T cells. The IL-7 receptor is a heterodimer of the common gamma chain, gammac, and the IL-7-specific IL-7Ralpha. IL-7 activates PI3K/Akt, Jak1/2, and Stat1, 3, and 5.

Human, Mouse, Rat

-20°C or -80°C

41116161