ILK-IN-2

MedChem Express

ILK-IN-2 [1333146-24-9]

5

1333146-24-9

Research Use Only

99.41

C30H30F3N5O

533.59

ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC 50 of 0.6 microM. ILK-IN-2 induces cell autophagy and apoptosis , showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase -dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models [1] [2] .

O=C(NC)CCC1=NN(C2=CC=C(N3CCNCC3)C=C2)C(C4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)=C1

-20°C,2°C to 8°C

12352200