Imatinib-13C,d3

MedChem Express

Imatinib-13C,d3

5

Research Use Only

C29 13CH31D3N7O

512.65

Imatinib-13C,d3 (STI571-13C,d3) is 13C labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively[1][2][3][4]. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV[5].

O=C(C1=CC=C(CN2CC[N]CC2)C=C1)NC3=CC=C(C)C(NC4=NC(C5=CN=CC=C5)=CC=N4)=C3.C[13C]([2H])([2H])[2H]

12352200