Immunoglobulin G Fab Fragment

Athens Research

Immunoglobulin G Fab Fragment

9

Biotherapeutics, Flow Cytometry, Immunohistochemistry, Antisera Production

Research Use Only

≥95% by SDS-PAGE. No reaction by IEP to antisera to human IgG-fc.

The IgG Fab (Fragment antigen-binding) fragment is a monovalent proteolytic product of Immunoglobulin G. Each Fab fragment retains the variable domains (VH and VL) responsible for antigen specificity while lacking the Fc-mediated effector functions, enabling targeted antigen neutralization without immune activation. This structural configuration prevents cross-linking-induced precipitation or cellular patching/capping, making Fab fragments ideal for precise antigen targeting in solution or on cell surfaces. Diagnostically, Fab fragments enable multiplex immunoassays by preventing Fc-mediated cross-reactivity, facilitating simultaneous detection of multiple antigens in flow cytometry and immunohistochemistry. Their monovalent nature ensures minimal background noise in assays requiring high specificity. Emerging applications include autoimmune disease management, where Fab fragments neutralize autoantibodies while circumventing complement activation. By combining targeted binding with reduced immunogenicity, IgG Fab fragments represent a versatile tool in both clinical and research settings.

more then 1 year

Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

-20C

41116100