
FACS analysis of LNCap cells using GTX57655 IMPA1 antibody. Cell Number: 1 x 10? cells Primary antibody: Red line Antibody amount: 2-5 microg
IMPA1 antibody [AT2G5]
GTX57655
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetIMPA1
Overview
- SupplierGeneTex
- Product NameIMPA1 antibody [AT2G5]
- Delivery Days Customer9
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDAT2G5
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID3612
- Target nameIMPA1
- Target descriptioninositol monophosphatase 1
- Target synonymsD-galactose 1-phosphate phosphatase; IMP; IMP 1; IMPA; IMPase 1; inositol monophosphatase 1; inositol(myo)-1(or 4)-monophosphatase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1; MRT59; myo-inositol monophosphatase 1; testicular tissue protein Li 94
- HostMouse
- IsotypeIgG1
- Protein IDP29218
- Protein NameInositol monophosphatase 1
- Scientific DescriptionThis gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203