More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/Importin 7 antibody [C3], C-term

Importin 7 antibody [C3], C-term

GTX106408
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetIPO7
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    GeneTex
  • Product Name
    Importin 7 antibody [C3], C-term
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by references (PMID:25999477)
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10527
  • Target name
    IPO7
  • Target description
    importin 7
  • Target synonyms
    Imp7; importin-7; RAN-binding protein 7; RANBP7
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO95373
  • Protein Name
    Importin-7
  • Scientific Description
    The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Rans GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Akt-mediated phosphorylation increases the binding affinity of hTERT for importin alpha to promote nuclear translocation. Jeong SA et al., 2015 Jun 15, J Cell Sci
    Read more
  • The p53-induced factor Ei24 inhibits nuclear import through an importin beta-binding-like domain. Lieu KG et al., 2014 May 12, J Cell Biol
    Read more
  • Bovine ephemeral fever rhabdovirus alpha1 protein has viroporin-like properties and binds importin beta1 and importin 7. Joubert DA et al., 2014 Feb, J Virol
    Read more