IMT1

AbMole BioScience

IMT1

9

2304621-31-4

Research Use Only

C21H21NO4

351.4

IMT1 is the first, specific and non-competitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 induces conformational changes in POLRMT that block substrate binding and transcription in a dose-dependent manner in vitro. IMT1 reduced deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in significant depletion of cellular amino acid levels.

CC(OC1=CC=C2C(=C1)OC(=O)C=C2C3=C(C)C=CC=C3)C(=O)N(C)C

12352200