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ProductsBack/Incensol acetate [34701-53-6]
Chemical Structure
Chemical Structure
Chemical Structure

Incensol acetate [34701-53-6]

Research Use Only
AG-CN2-0484
AdipoGen Life Sciences
CAS Number34701-53-6
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight348.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Incensol acetate
  • Delivery Days Customer
    10
  • CAS Number
    34701-53-6
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Formulation
    Liquid
  • Molecular Formula
    C22H36O3
  • Molecular Weight
    348.5
  • Scientific Description
    Chemical. CAS: 34701-53-6. Formula: C22H36O3. MW: 348.5. Semisynthetic from incensol (isolated from Boswellia papyrifera). Component of the frankincense essential oil. Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. Less powerful TRPV3 agonist than incensol (Prod. No. AG-CN2-0482). Shows in vivo neuroprotective properties. Causes anxiolytic-like and antidepressive-like behavioral effects in wild-type (WT) mice. Anti-inflammatory agent. Shown to have COX-1 and COX-2 inhibitory activity and cytotoxic activity against selected cancer cell lines. - Component of the frankincense essential oil. Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. Less powerful TRPV3 agonist than incensol (Prod. No. AG-CN2-0482). Shows in vivo neuroprotective properties. Causes anxiolytic-like and antidepressive-like behavioral effects in wild-type (WT) mice. Anti-inflammatory agent. Shown to have COX-1 and COX-2 inhibitory activity and cytotoxic activity against selected cancer cell lines.
  • SMILES
    C/C1=C\CC/C(C)=C/C[C@]2(C(C)C)CC[C@@](C)(O2)[C@@H](OC(C)=O)CC1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri: T. Akihisa, et al.; Biol. Pharm. Bull. 29, 1976 (2006)
  • Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation: A. Moussaieff, et al.; Mol. Pharmacol. 72, 1657 (2007)
  • Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii: A. Moussaieff, et al.; J. Cereb. Blood Flow Metab. 28, 1341 (2008)
  • Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain: A. Moussaieff, et al.; FASEB J. 22, 3024 (2008)
  • Protective effects of incensole acetate on cerebral ischemic injury: A. Moussaieff, et al.; Brain Res. 1443, 89 (2012)
  • Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals: A. Moussaieff, et al.; J. Psychopharmacol. 26, 1584 (2012)
  • Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity: S.I. Ali, et al.; Nat. Prod. Commun. 8, 1365 (2013)
  • Neuroactive and anti-inflammatory frankincense cembranes: A structure-activity study: F. Pollastro, et al.; J. Nat. Prod. 79, 1762 (2016)