Indibulin

MedChem Express

Indibulin [204205-90-3]

10

204205-90-3

Research Use Only

99.89

C22H16ClN3O2

389.83

Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis [1] .

O=C(NC1=CC=NC=C1)C(C2=CN(CC3=CC=C(Cl)C=C3)C4=C2C=CC=C4)=O

-20°C,2°C to 8°C

12352200