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Chemical Structure
Chemical Structure
Chemical Structure

INDY [1169755-45-6]

Research Use Only
AG-CR1-3665
AdipoGen Life Sciences
CAS Number1169755-45-6
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight235.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    INDY [1169755-45-6]
  • Delivery Days Customer
    10
  • CAS Number
    1169755-45-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C12H13NO2S
  • Molecular Weight
    235.3
  • Scientific Description
    Chemical. CAS: 1169755-45-6. Formula: C12H13NO2S. MW: 235.3. Synthetic. Potent and selective ATP-competitive DYRK1A and DYRK1B inhibitor (IC50=240nM and 230nM respectively). Binds at the ATP-binding cleft of the enzyme. Inhibits also DYRK2, DYRK3, CLK1, CLK4, casein kinase 1 (CSNK1D) and PIM1 (>90% inhibition at the same concentration). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells. Shown to induce regeneration and expansion of rat and adult human beta-cells in vivo or ex vivo. - Potent and selective ATP-competitive DYRK1A and DYRK1B inhibitor (IC50=240nM and 230nM respectively). Binds at the ATP-binding cleft of the enzyme. Inhibits also DYRK2, DYRK3, CLK1, CLK4, casein kinase 1 (CSNK1D) and PIM1 (>90% inhibition at the same concentration). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells. Shown to induce regeneration and expansion of rat and adult human beta-cells in vivo or ex vivo.
  • SMILES
    OC1=CC=C(S/C(N2CC)=C\C(C)=O)C2=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A: Y. Ogawa, et al.; Nat. Commun. 1, 86 (2010)
  • Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth: N. Pozo, et al.; J. Clin. Invest. 123, 2475 (2013)
  • A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication: P. Wang, et al.; Nat. Med. 21, 383 (2015)