INDY

MedChem Express

INDY [1169755-45-6]

10

1169755-45-6

Research Use Only

99.32

C12H13NO2S

235.30

INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 microM and 0.23 microM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 microM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells[1][2].

CC(/C=C1SC2=CC=C(O)C=C2N\1CC)=O

-20°C

12352200