Inobrodib

MedChem Express

Inobrodib [2222941-37-7]

10

2222941-37-7

Research Use Only

99.94

C30H32F2N4O3

534.60

Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain . Inobrodib binds to p300 and CBP with K d values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a K d of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression [1] .

O=C1N(C2=CC=C(F)C(F)=C2)[C@H](C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@H]6CC[C@H](OC)CC6)CCC1

-20°C,2°C to 8°C

12352200