ProductsBack/INSM1 antibody [A-8]

INSM1 antibody [A-8]

Name: INSM1 antibody [A-8]
SKU: GTX01723_G10
Availability: BackOrder

GTX01723

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman

TargetINSM1

Overview

Supplier
GeneTex
Product Name
INSM1 antibody [A-8]
Delivery Days Customer
9
Application Supplier Note
IHC-P: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
A-8
Concentration
0.1 mg/ml
Conjugate
Unconjugated
Gene ID3642
Target name
INSM1
Target description
INSM transcriptional repressor 1
Target synonyms
IA-1, IA1, insulinoma-associated protein 1, insulinoma-associated 1, zinc finger protein IA-1
Host
Mouse
Isotype
IgG1
Protein IDQ01101
Protein Name
Insulinoma-associated protein 1
Scientific Description
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008]
Reactivity
Human
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Tsai HK, Hornick JL, Vivero M. INSM1 expression in a subset of thoracic malignancies and small round cell tumors: rare potential pitfalls for small cell carcinoma. Mod Pathol. 2020,33(8):1571-1580. doi: 10.1038/s41379-020-0517-0
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Staaf J, Tran L, Söderlund L, et al. Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers. Arch Pathol Lab Med. 2020,144(9):1075-1085. doi: 10.5858/arpa.2019-0250-OA
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Shinji S, Sasaki N, Yamada T, et al. Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor. Cancer Sci. 2019,110(12):3708-3717. doi: 10.1111/cas.14221
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Švajdler M, Mezencev R, Šašková B, et al. Triple marker composed of p16, CD56, and TTF1 shows higher sensitivity than INSM1 for diagnosis of pulmonary small cell carcinoma: proposal for a rational immunohistochemical algorithm for diagnosis of small cell carcinoma in small biopsy and cytology specimens. Hum Pathol. 2019,85:58-64. doi: 10.1016/j.humpath.2018.10.016
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Mukhopadhyay S, Dermawan JK, Lanigan CP, et al. Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections. Mod Pathol. 2019,32(1):100-109. doi: 10.1038/s41379-018-0122-7
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