Insulin Receptor beta antibody
GTX101136
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetINSR
Overview
- SupplierGeneTex
- Product NameInsulin Receptor beta antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.31 mg/ml
- ConjugateUnconjugated
- Gene ID3643
- Target nameINSR
- Target descriptioninsulin receptor
- Target synonymsCD220, HHF5, insulin receptor, IR
- HostRabbit
- IsotypeIgG
- Protein IDP06213
- Protein NameInsulin receptor
- Scientific DescriptionAfter removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Tucker TR, Knitter CA, Khoury DM, et al. An inducible model of chronic hyperglycemia. Dis Model Mech. 2023,16(8). doi: 10.1242/dmm.050215Read this paper
- Jafari-Rastegar N, Hosseininia HS, Jalilvand E, et al. Oral administration of nano-tyrosol reversed the diabetes-induced liver damage in streptozotocin-induced diabetic rats. J Diabetes Metab Disord. 2023,22(1):297-305. doi: 10.1007/s40200-022-01133-wRead this paper
- Su Y, Liu N, Sun R, et al. Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT/GSK-3β signaling pathway and intestinal microbiota. Front Pharmacol. 2023,14:1115387. doi: 10.3389/fphar.2023.1115387Read this paper
- Dominici FP, Veiras LC, Shen JZY, et al. Activation of AT(2) receptors prevents diabetic complications in female db/db mice by NO-mediated mechanisms. Br J Pharmacol. 2020,177(20):4766-4781. doi: 10.1111/bph.15241Read this paper
- Huang TW, Li ST, Wang YH, et al. Regulation of chitosan-mediated differentiation of human olfactory receptor neurons by insulin-like growth factor binding protein-2. Acta Biomater. 2019,97:399-408. doi: 10.1016/j.actbio.2019.08.022Read this paper
- Choi KM, Yoo HS. 3,3'-Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3-L1 Adipocytes. Obesity (Silver Spring). 2018,26(7):1153-1160. doi: 10.1002/oby.22145Read this paper
- Chen YT, Lin WD, Liao WL, et al. PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes. Oncotarget. 2015,6(15):12997-3005.Read this paper
Datasheet
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