Integrin alpha 4 antibody [HP2/1]
GTX76407
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
Product group Antibodies
TargetITGA4
Overview
- SupplierGeneTex
- Product NameIntegrin alpha 4 antibody [HP2/1]
- Delivery Days Customer9
- Application Supplier NoteFACS: 1microg/5 x 105 cells. Neutralizing/Inhibition: . *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHP2/1
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID3676
- Target nameITGA4
- Target descriptionintegrin subunit alpha 4
- Target synonymsCD49D, IA4, integrin alpha-4, 269C wild type, CD49 antigen-like family member D, VLA-4 subunit alpha, alpha 4 subunit of VLA-4 receptor, antigen CD49D, alpha-4 subunit of VLA-4 receptor, integrin alpha-IV, very late activation protein 4 receptor, alpha 4 subunit
- HostMouse
- IsotypeIgG1
- Protein IDP13612
- Protein NameIntegrin alpha-4
- Scientific DescriptionThe gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohns disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Hernandez AA, Foster GA, Soderberg SR, et al. An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes. J Immunol. 2020,205(10):2806-2820. doi: 10.4049/jimmunol.2000485Read this paper
- Abplanalp WT, Conklin DJ, Cantor JM, et al. Enhanced Integrin α4β1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes. Diabetes. 2016,65(11):3505-3515.Read this paper





![FACS analysis of human peripheral blood lymphocytes using GTX01494-07 Integrin alpha 4 antibody [9F10] (APC). Solid lone : primary antibody Dashed line : isotype control antibody amount : 0.25 microg (5 microl)](https://www.genetex.com/upload/website/prouct_img/normal/GTX01494-07/GTX01494-07_20200428_FACS18_w_23053121_925.webp)
![FACS analysis of human peripheral blood lymphocytes using GTX01494-08 Integrin alpha 4 antibody [9F10] (PE). Solid lone : primary antibody Dashed line : isotype control antibody amount : 0.25 microg (5 microl)](https://www.genetex.com/upload/website/prouct_img/normal/GTX01494-08/GTX01494-08_20200428_FACS109_w_23053121_607.webp)