Integrin alpha 4 antibody [HP2/1]
GTX76407
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
Product group Antibodies
ReactivityBovine, Equine, Feline, Goat, Human, Mammals, Mink, Monkey, Mouse, Porcine, Primate, Rabbit, Rat
Overview
- SupplierGeneTex
- Product NameIntegrin alpha 4 antibody [HP2/1]
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHP2/1
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohns disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
- ReactivityBovine, Equine, Feline, Goat, Human, Mammals, Mink, Monkey, Mouse, Porcine, Primate, Rabbit, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes. Hernandez AA et al., 2020 Nov 15, J ImmunolRead more
- Enhanced Integrin alpha4beta1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes. Abplanalp WT et al., 2016 Nov, DiabetesRead more