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ProductsBack/Integrin alpha 6 antibody [NKI-GoH3]
Staining of human peripheral blood platelets with Rat anti Human CD49f:Biotin
Staining of human peripheral blood platelets with Rat anti Human CD49f:Biotin
Staining of human peripheral blood platelets with Rat anti Human CD49f:Biotin

Integrin alpha 6 antibody [NKI-GoH3]

GTX76413
GeneTex
ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
Product group Antibodies
ReactivityCanine, Human, Monkey, Mouse
TargetITGA6
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Overview

  • Supplier
    GeneTex
  • Product Name
    Integrin alpha 6 antibody [NKI-GoH3]
  • Delivery Days Customer
    9
  • Applications
    Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    NKI-GoH3
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3655
  • Target name
    ITGA6
  • Target description
    integrin subunit alpha 6
  • Target synonyms
    CD49f, ITGA6A, ITGA6B, JEB6, VLA-6, integrin alpha-6, CD49 antigen-like family member F, integrin alpha6B, integrin, alpha 6, very late activation protein 6
  • Host
    Rat
  • Isotype
    IgG2a
  • Protein IDP23229
  • Protein Name
    Integrin alpha-6
  • Scientific Description
    The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
  • Reactivity
    Canine, Human, Monkey, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Zevian S, Winterwood NE, Stipp CS. Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated by α3β1 versus α6β4 integrin. J Biol Chem. 2011,286(9):7496-506. doi: 10.1074/jbc.M110.173583
    Read this paper
  • Bubier JA, Sproule TJ, Alley LM, et al. A mouse model of generalized non-Herlitz junctional epidermolysis bullosa. J Invest Dermatol. 2010,130(7):1819-28. doi: 10.1038/jid.2010.46
    Read this paper
  • Rowland TJ, Miller LM, Blaschke AJ, et al. Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin. Stem Cells Dev. 2010,19(8):1231-40. doi: 10.1089/scd.2009.0328
    Read this paper
  • Sasaki K, Pardee AD, Qu Y, et al. IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors. J Immunother. 2009,32(8):793-802. doi: 10.1097/CJI.0b013e3181acec1e
    Read this paper
  • Winterwood NE, Varzavand A, Meland MN, et al. A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5. Mol Biol Cell. 2006,17(6):2707-21.
    Read this paper

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Figure 1. Western blot analysis of ITGA6 using anti-ITGA6 antibody (A01693). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human A431 whole cell lysates, Lane 2: human A549 whole cell lysates, Lane 3: rat kidney tissue lysates, Lane 4: mouse kidney tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-ITGA6 antigen affinity purified polyclonal antibody (Catalog # A01693) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for ITGA6 at approximately 127 kDa. The expected band size for ITGA6 is at 127 kDa.
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Lane 1: SW480 cell lysates; Lane 2: A549 cell lysates; Lane 3: Huvec cell lysates; Lane 4: A431 cell lysates probed with Integrin alpha 6 Polyclonal Antibody, Unconjugated (bs-2641R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.
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