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ProductsBack/Integrin alpha 6 antibody [NKI-GoH3]
GTX76413 FACS Image
GTX76413 FACS Image
GTX76413 FACS Image

Integrin alpha 6 antibody [NKI-GoH3]

Research Use Only
GTX76413
GeneTex
ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
DownloadDatasheet
Product group Antibodies
ReactivityCanine, Human, Monkey, Mouse
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Overview

  • Supplier
    GeneTex
  • Product Name
    Integrin alpha 6 antibody [NKI-GoH3]
  • Delivery Days Customer
    10
  • Applications
    Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    NKI-GoH3
  • Concentration
    1 mg/ml
  • Host
    Rat
  • Isotype
    IgG
  • Scientific Description
    The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
  • Reactivity
    Canine, Human, Monkey, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5. Winterwood NE et al., 2006 Jun, Mol Biol Cell
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  • IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors. Sasaki K et al., 2009 Oct, J Immunother
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  • Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated by alpha3beta1 versus alpha6beta4 integrin. Zevian S et al., 2011 Mar 4, J Biol Chem
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