Interferon gamma Receptor 1 antibody

GeneTex

Interferon gamma Receptor 1 antibody

9

WB: 0.1 microg/ml. ICC/IF: 5-15 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, Neutralisation/Blocking

Research Use Only

Polyclonal

Unconjugated

Liquid

IFNGR1

interferon gamma receptor 1

antiviral protein, type 2; AVP, type 2; CD119; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; IFN-gamma-R-alpha; IFNGR; IMD27A; IMD27B; immune interferon receptor 1; interferon gamma receptor 1; interferon-gamma receptor alpha chain

Goat

IgG

Interferon gamma receptor 1

The IFNG receptor complex is composed of two type I membrane proteins, IFNGRI (IFNGR alpha) and IFNGR2 (IFNGR beta). Both receptor proteins are members of the type II cytokine receptor family and share 52% overall sequence identity. The IFNG receptor is constitutively expressed in most cell types. Soluble IFNG has been detected in biological fluids. IFNG R1 is required for ligand-binding and signaling. It binds to IFNG with high affinity and is a potent IFNG antagonist. In signal transduction, IFNG induces tyrosine phosphorylation of IFNG R1 leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFNg-induced gene transcription. Human IFNGRI, a 227 amino acid residue protein, has a calculated molecular mass of approximately 25 kDa. As a result of glycosylation, the recombinant IFNGRI migrates as a 40 to 50 kDa protein in SDS-PAGE. Human and mouse IFNGRI share approximately 52% amino acid sequence identity and each interacts with IFNG in a strictly species-specific manner.

Human

-20°C or -80°C,2°C to 8°C

12352203