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Product image
InVivoMAb anti-human CD3
BE0231
ApplicationsFlow Cytometry, Other Application, Purification/Extraction/Isolation
Product group Antibodies
ReactivityHuman
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-human CD3
- Delivery Days Customer7
- ApplicationsFlow Cytometry, Other Application, Purification/Extraction/Isolation
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDUCHT1 (Leu-4) (T3)
- Concentration4-11 mg/ml
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe UCHT1 (Leu-4)(T3) monoclonal antibody reacts with human CD3ε a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3εis one of five polypeptide chains that combine to form the TCR complex. CD3εis expressed on T lymphocytes NK-T cells and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling T lymphocyte activation and antigen recognition. Crosslinking of the TCR via immobilized UCHT1 (Leu-4)(T3) antibody is commonly used to activate T cells in vitro.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues. Wunderlich M et al., 2014 Jun 12, BloodRead more
- Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials. Woo JH et al., 2010, Methods Mol BiolRead more
- Differential antibody binding to the surface alphabetaTCR.CD3 complex of CD4+ and CD8+ T lymphocytes is conserved in mammals and associated with differential glycosylation. Rossi NE et al., 2008 Oct, Int ImmunolRead more
- Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Arnett KL et al., 2004 Nov 16, Proc Natl Acad Sci U S ARead more
