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InVivoMAb anti-human CD32 (FcgammaRIIA)
BE0224
ApplicationsFlow Cytometry, ELISA, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-human CD32 (FcgammaRIIA)
- Delivery Days Customer7
- ApplicationsFlow Cytometry, ELISA, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDIV.3
- Concentration4-11 mg/ml
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionThe IV.3 monoclonal antibody reacts with human CD32 also known as FcγRII and FCRII, a 40 kDa polymorphic transmembrane glycoprotein and an Ig superfamily member. CD32 is expressed on monocytes/macrophages, granulocytes, platelets and B cells. CD32 enables interaction between Fc γ RII-expressing cells and opsonized antigen or IgG-containing immune complexes. This allows CD32 to function in the activation or inhibition of immune responses including degranulation, phagocytosis, ADCC, cytokine release, and B cell proliferation. The IV.3 antibody has been shown to block the biological effects of CD32 in vitro. Additionally, IV.3 f(ab’)2 fragments have been used to block CD32 in vivo in transgenic mice expressing human CD32.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- SDF-1alpha is a novel autocrine activator of platelets operating through its receptor CXCR4. Walsh TG et al., 2015 Jan, Cell SignalRead more
- A novel FcgammaRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcgammaRIIa downstream signaling. Flinsenberg TWH et al., 2014 Nov, Clin ImmunolRead more
- Shifting FcgammaRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis. Ben Mkaddem S et al., 2014 Sep, J Clin InvestRead more
- Polymorphisms and interspecies differences of the activating and inhibitory FcgammaRII of Macaca nemestrina influence the binding of human IgG subclasses. Trist HM et al., 2014 Jan 15, J ImmunolRead more
- Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcgammaR antagonists that inhibit IgG-mediated effector functions. Stemerding AM et al., 2013 Jul 1, J ImmunolRead more
- Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. van der Aar AM et al., 2013 May, J Invest DermatolRead more
- Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization. Veri MC et al., 2007 Jul, ImmunologyRead more
- A dominant role for FcgammaRII in antibody-enhanced dengue virus infection of human mast cells and associated CCL5 release. Brown MG et al., 2006 Dec, J Leukoc BiolRead more
