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InVivoMAb anti-human CD54 (ICAM-1)
BE0020-2
ApplicationsImmunoFluorescence, Other Application
Product group Antibodies
ReactivityHuman
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-human CD54 (ICAM-1)
- Delivery Days Customer7
- ApplicationsImmunoFluorescence, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDR6-5-D6
- Concentration4-11 mg/ml
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionThe R6-5-D6 monoclonal antibody reacts with human CD54 also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a single-chain transmembrane glycoprotein with a polypeptide core of 55 kDa and a member of the Ig superfamily. CD54 is typically expressed on non-hematopoietic cells such as endothelial cells, thymic epithelial cells, and fibroblasts but can also be expressed on macrophages, T-lymphoblasts, germinal center B cells and dendritic cells. CD54 is a ligand for LFA-1, a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via CD54/LFA-1 and then transmigrate into tissues. Pro-inflammatory cytokines such as IL-1, TNF and IFNγ induce CD54 expression on endothelial cells and fibroblasts. The R6-5-D6 antibody has been reported to inhibit the interaction of CD54 with leukocytes, thereby decreasing leukocyte adhesion to the vascular endothelium and inflammatory tissue injury.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Cortactin regulates the activity of small GTPases and ICAM-1 clustering in endothelium: Implications for the formation of docking structures. Vestweber D et al., 2013 Jan 1, Tissue BarriersRead more
- Choice of resident costimulatory molecule can influence cell fate in human naive CD4+ T cell differentiation. Williams KM et al., 2011, Cell ImmunolRead more
- Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. Schnoor M et al., 2011 Aug 1, J Exp MedRead more
