InVivoMAb anti-human CTLA-4 (CD152)

Name: InVivoMAb anti-human CTLA-4 (CD152)
SKU: BE0190_B56
Availability: BackOrder

BE0190

ApplicationsFlow Cytometry, Neutralisation/Blocking

Product group Antibodies

ReactivityHuman

Overview

Supplier
Bio X Cell
Product Name
InVivoMAb anti-human CTLA-4 (CD152)
Delivery Days Customer
7
Applications
Flow Cytometry, Neutralisation/Blocking
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
BN13
Concentration
4-11 mg/ml
Estimated Purity
>95%
Host
Mouse
Isotype
IgG2a
Scientific Description
The BN13 monoclonal antibody reacts with human CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28 family of the Ig superfamily. CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4 negatively regulates cell-mediated immune responses. CTLA-4 plays roles in induction and/or maintenance of immunological tolerance, thymocyte development, and regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation has been demonstrated in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a lymphoproliferative disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through immune checkpoint blockade. The BN13 antibody has been shown to neutralize CTLA-4 in vitro.
Reactivity
Human
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. Bhela S et al., 2015 Mar 1, J Immunol
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Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization. Gideon HP et al., 2015 Jan, PLoS Pathog
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Stromal cells B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line. Otani T et al., 2011 Feb, Immunol Cell Biol
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HIV-1 impairs in vitro priming of naive T cells and gives rise to contact-dependent suppressor T cells. Che KF et al., 2010 Aug, Eur J Immunol
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Antigen-induced regulatory T cells in HBV chronically infected patients. Barboza L et al., 2007 Nov 10, Virology
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CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells. Pistillo MP et al., 2003 Jan 1, Blood
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