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InVivoMAb anti-human CTLA-4 (CD152)
BE0190
ApplicationsFlow Cytometry, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-human CTLA-4 (CD152)
- Delivery Days Customer7
- ApplicationsFlow Cytometry, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDBN13
- Concentration4-11 mg/ml
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionThe BN13 monoclonal antibody reacts with human CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28 family of the Ig superfamily. CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4 negatively regulates cell-mediated immune responses. CTLA-4 plays roles in induction and/or maintenance of immunological tolerance, thymocyte development, and regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation has been demonstrated in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a lymphoproliferative disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through immune checkpoint blockade. The BN13 antibody has been shown to neutralize CTLA-4 in vitro.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. Bhela S et al., 2015 Mar 1, J ImmunolRead more
- Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization. Gideon HP et al., 2015 Jan, PLoS PathogRead more
- Stromal cells B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line. Otani T et al., 2011 Feb, Immunol Cell BiolRead more
- HIV-1 impairs in vitro priming of naive T cells and gives rise to contact-dependent suppressor T cells. Che KF et al., 2010 Aug, Eur J ImmunolRead more
- Antigen-induced regulatory T cells in HBV chronically infected patients. Barboza L et al., 2007 Nov 10, VirologyRead more
- CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells. Pistillo MP et al., 2003 Jan 1, BloodRead more
