InVivoMAb anti-human/monkey CD20

Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy. Li R et al., 2015 Oct 21, Sci Transl Med

Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes. Hu C et al., 2013 Aug, Diabetes

The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice. Xiang Y et al., 2012 May 15, J Immunol

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Keren Z et al., 2011 Mar 17, Blood

B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity. Weber MS et al., 2010 Sep, Ann Neurol

Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Mack CL et al., 2004 Jul, Pediatr Res

Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure. Polyak MJ et al., 2002 May 1, Blood