InVivoMAb anti-human/monkey MDR-1 (CD243)

The strong in vivo anti-tumor effect of the UIC2 monoclonal antibody is the combined result of Pgp inhibition and antibody dependent cell-mediated cytotoxicity. Szaloki G et al., 2014, PLoS One

Pgp inhibition by UIC2 antibody can be followed in vitro by using tumor-diagnostic radiotracers, 99mTc-MIBI and 18FDG. Krasznai ZT et al., 2010 Dec 23, Eur J Pharm Sci

Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. Goda K et al., 2007 Jan, J Pharmacol Exp Ther

Detection of P-glycoprotein in squamous cell carcinomas of the head and neck. Kelley DJ et al., 1993 Apr, Arch Otolaryngol Head Neck Surg

Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Mechetner EB et al., 1992 Jul 1, Proc Natl Acad Sci U S A