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InVivoMAb anti-human/monkey MHC class II (HLA-DR)

Research Use Only
BE0306
Bio X Cell
ApplicationsFlow Cytometry, Western Blot, Neutralisation/Blocking, Other Application
Product group Antibodies
ReactivityHuman, Monkey
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoMAb anti-human/monkey MHC class II (HLA-DR)
  • Delivery Days Customer
    7
  • Applications
    Flow Cytometry, Western Blot, Neutralisation/Blocking, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    L243
  • Concentration
    4-11 mg/ml
  • Estimated Purity
    >95%
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    The L243 monoclonal antibody reacts with the human and monkey MHC class II, HLA-DR. HLA-DR is a transmembrane glycoprotein composed of an α chain (36 kDa) and a β chain (27 kDa). HLA-DR is expressed primarily on antigen presenting cells such as B cells, monocytes, macrophages, thymic epithelial cells and activated T cells. HLA-DR is critical for the presentation of peptides to CD4+ T cells.
  • Reactivity
    Human, Monkey
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Citrullinated Vimentin Presented on MHC-II in Tumor Cells Is a Target for CD4+ T-Cell-Mediated Antitumor Immunity. Brentville VA et al., 2016 Feb 1, Cancer Res
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  • The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01. Hirasawa M et al., 2015, PLoS One
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  • Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic Plasmodium falciparum and P. vivax infection. Kho S et al., 2015 Aug, Infect Immun
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  • Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. Kalka-Moll WM et al., 2002 Dec 1, J Immunol
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  • Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation. Esser MT et al., 2001 Jul, J Virol
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  • Lipopolysaccharide stimulates the proliferation of human CD56+CD3- NK cells: a regulatory role of monocytes and IL-10. Goodier MR et al., 2000 Jul 1, J Immunol
    Read more

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