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InVivoMAb anti-mouse BTLA (CD272)
BE0304
ApplicationsFlow Cytometry, Other Application
Product group Antibodies
ReactivityMouse
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse BTLA (CD272)
- Delivery Days Customer7
- ApplicationsFlow Cytometry, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID6F7
- Concentration4-11 mg/ml
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe 6F7 monoclonal antibody reacts with mouse B- and T-lymphocyte attenuator (BTLA) also known as CD272. BTLA is an Ig superfamily member which is expressed on B cells, T cells, macrophages, dendritic cells, NK cells, and NKT cells. Like PD-1 and CTLA-4, BTLA interacts with a B7 homolog, B7-H4. However, unlike PD-1 and CTLA-4, BTLA displays T cell inhibition via interaction with tumor necrosis family receptors, not just the B7 family of cell surface receptors. BTLA is a ligand for herpes virus entry mediator (HVEM). BTLA-HVEM complexes have been shown to negatively regulate T cell immune responses. There are conflicting reports concerning the activity of the 6F7 antibody. In some cases, the antibody is reported to deplete BTLA+ B and CD4 T cells while in others the antibody is reported as having agonistic activity. See the references for details.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication. Zelinskyy G et al., 2011 Oct 1, J ImmunolRead more
- BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice. Truong W et al., 2009 Jul, J Leukoc BiolRead more
- A crucial role for HVEM and BTLA in preventing intestinal inflammation. Steinberg MW et al., 2008 Jun 9, J Exp MedRead more
- Combined coinhibitory and costimulatory modulation with anti-BTLA and CTLA4Ig facilitates tolerance in murine islet allografts. Truong W et al., 2007 Dec, Am J TransplantRead more
- B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in anergic CD4+ T cells. Hurchla MA et al., 2005 Mar 15, J ImmunolRead more
