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InVivoMAb anti-mouse CD172a (SIRPalpha)

BE0322
Bio X Cell
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, Neutralisation/Blocking
Product group Antibodies
ReactivityMouse
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoMAb anti-mouse CD172a (SIRPalpha)
  • Delivery Days Customer
    7
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Western Blot, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    P84
  • Concentration
    4-11 mg/ml
  • Estimated Purity
    >95%
  • Host
    Rat
  • Isotype
    IgG1
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Yanagita T, Murata Y, Tanaka D, et al. Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy. JCI Insight. 2017,2(1):e89140. doi: 10.1172/jci.insight.89140
    Read this paper
  • Zen K, Guo Y, Bian Z, et al. Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state. Nat Commun. 2013,4:2436. doi: 10.1038/ncomms3436
    Read this paper
  • Koskinen C, Persson E, Baldock P, et al. Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling. J Biol Chem. 2013,288(41):29333-44. doi: 10.1074/jbc.M113.494591
    Read this paper
  • Teraoka Y, Ide K, Morimoto H, et al. Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPα inhibitory signaling in mice. PLoS One. 2013,8(3):e58359. doi: 10.1371/journal.pone.0058359
    Read this paper
  • Lundberg P, Koskinen C, Baldock PA, et al. Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction. Biochem Biophys Res Commun. 2007,352(2):444-8.
    Read this paper
  • Oldenborg PA, Gresham HD, Lindberg FP. CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis. J Exp Med. 2001,193(7):855-62.
    Read this paper